I'm trying to think about those outside of "me" though, like some knucklehead little kid that might find it fun to run up to the big man and squeeze the trigger on his position one Colt Series 80 1991A1. Possible, sure, and while situational awareness is paramount, sometimes you just don't see/hear those little buggers until they're right up on you. I should see him, it seems logical that I should, but sometimes things happen that you cannot account for in life. So, safety on. It's just a single switch, and easy to reach with the thumb, and I'm not a fast draw competitor that needs a 0.48 second draw and fire.
(Concealed) Kahr CW45 - No safety, one in the pipe, but the trigger is covered by the holster, unlike my single action auto.
(Open) Ruger Blackhawk .45 Long Colt - no safety, revolver, trigger exposed by it's a single action and the retention covers the back of the hammer (standard revolver holster)