Read lots of reviews. Usually something that shoots such different kinds of things doesn't do either particularly well. Remember that the .45/.410 revolver was a failed concept in the Thunder Five revolver. Then Taurus introduced it with the benefit of one of the biggest marketing campaigns the shooting world has ever seen. I still meet people that swear their Judge is the most powerful revolver ever made. Anyway, S&W is just grabbing onto Taurus' coattails (after decades of the other way around) and one-upped them (literally, six shots instead of five) plus gave it .45 ACP capability.
I'm not saying it's not an acceptable sidearm. Just as long as you know what you are getting.
But yes, my two most oft carried sidearms are chambered for .45 ACP or .45 Colt. They are capable of any self-defense encounter with any number of legs.