In his book, No Second Place Winner, Bill Jordan very briefly discusses one or two disadvantages against cross-draw. I think he even cites that law-enforcement cancelled cross-draw for one of these reasons (Jordan rose high in the Border Patrol and was a goodguy gunman of some reputation back in the day. Say 1940's-1960's.)
When facing an adversary, cross-draw presents the butt to your opponent. A gun-grab, according to Jordan, is very easy from this position. His book has a photo of a cop putting a badguy into a cruiser or something to show how easy from the positioning--not something that an OCer is likely to encounter.
Also, if your adversary is inside your reactionary gap (the space that gives you time to react) and in front of you, he can easily pin your gun in your holster by trapping your hand on your gun as you reach for it.
Now, if you think through on it a little bit, about the only time these will be a problem is when you are facing an antagonist who is not yet a real threat. Just heated, lets call it. And, thus maybe gets within arms reach during a heated discussion. This problem is easily solved by maintaining distance if you can. If you can't back up very far, its a different story. I kinda think those circumstances are likely to be rare enough as to not be the deciding factor. So, those alone didn't dissuade me.
But, what if you encounter a situation where lethal force is not justified, but you have to defend yourself against, say, a fist-fight assault or something. Now, your gun is within easy reach of the assailant, and if he decides to escalate by pulling a gun--yours--suddenly he's in a great position to do so if he's mostly in front or a little to your weak side where the cross-draw holster is located.
Between, these three circumstances, I decided against cross-draw.