I carry a G 21 in an Uncle Mikes LE Kydex holster in the cross draw 10-11 o'clock position. For me, this works the best at home, in the car, out and about, generally everywhere. Now, for me the reason I carry cross draw is I feel I can better defend against a grab than I could from a side draw position. That's just me, and I can see both sides plus's/minus's arguments for why they carry as they do. The other deciding factor for me is, being right handed and using my shoulder rig, it is basically the same draw motion. Shoulder harness draw IS a cross draw, for a right handed shooter, right? So, regardless of which holster I'm wearing that particular day, the draw I train with remains mostly the same.
Now, with the CZ 82, I only have holsters that are normal draw (currently), which doesn't bother me much, since the CZ doesn't interfere with the G 21's position, and actually would detract from the detection of the G 21, since one is a drop leg, and the other is a belt holster ( both with straps ). So, when I'm wearing both, one, both or the other is going to be noticed, presenting a would-be criminal a dilemma, and then the situation determines the rest.
I don't plan on remaining still either way, and if I have to walk/run away to avoid escalation or taking a life, that would be my first choice. If the situation determines I must draw and shoot, then so be it. My first line of defense is not to place myself in positions where I have no options or an out - that should be everyones primary defense. Brains first, force second, unless the situation is forced right from the beginning, then our training and instincts should take over. So far, in the times I have carried and the possibility of using a firearm presented itself, brains won out over force.