Is your CZ 75 a single action only model - so you would be carrying with the hammer back with the safety on? I have personally never even carried a gun that had a safety. I have a da/sa semi auto and a double action revolver. I was also a bit nervous about carrying without a safety at first, but the "human safety" as you mention is by far the most important one you have. It should be fine to carry in a good holster. Don't go putting the gun in your front pocket along with your keys and other junk that can get caught on the trigger (although your CZ would probably be a little big to have to worry about doing that anyway). I'm sure others will chime in with more specific info on your model firearm as well.