My g/f recently purchased a Walther P22. We thought we were having feeding problems at first, but it turns out I was thumbing the slide lock, which was causing the issue. Since then we haven't had any problems. The gun IS smaller in size compared to "full-sized" handguns, but it is not uncomfortable to shoot. As far as I'm concerned, the P22 was designed to be a "tactical" .22 handgun. It lends itself very well to being carried as a defensive weapon, regardless of the caliber.
I think the P22 makes a very good multi-purpose .22 pistol. If you're only looking for a range shooter, the Ruger's are awesome as well, and probably a bit more accurate. You would be happy with either one of them, I'm sure.