I have fired the USP when I was trying out a bunch of .40-caliber handguns at Sam's to figure out which fit me best and it didn't fit me well at all.
Oddly enough, the subcompact GLOCK 27 was best fit for me, which obviously is different for each person.
Now, as for reliability, I'd personally stay away from the USP. They're pretty, but you better not get it near any dirt or grime. This torture test always gives me 'warm fuzzies' to know I carry my G27 when I step out the door (and they test a USP compact .45 in a couple of the tests): http://www.theprepared.com/index.php...id=90&Item
If the grip angle and everything fits you well, I'm sure there are other guns out there that are similar with better reliability. Some that come to mind that I'd put up there with GLOCK are the 1911, Springfield XD, and Smith & Wesson M&P (the latter two not having a long time on the market, but showing promise in some torture tests I've seen).