1. With an Ohio CHL or recognized credential from another state, carry in glove box or closed center console is legal, locked or otherwise.
2. If your wife who does not have a CHL and is alone in the car with a loaded firearm, that is a crime.
3. If you have a CHL and are in the car, it doesn't matter who's driving, so long as the loaded firearm is carried in accordance with the ORC (in holster on YOUR body, in glove box, in center console, in closed container, etc.).