imported post
The most effective thing you will ever use on large game (bear, elk, moose, bison) is a RIFLE cartridge. That said, if you really want to carry a hand gun that will stop something like that, it needs to chamber a rifle round.
Some examples of this are the 454 casull, the 480 Ruger, the 500 S&W. Magnum Research makes a 45-70 in 6 shot revolver as well.
These guns are pushing 300 + grains at velocities well over 1500 fps, this will stop ANYTHING that walks on this continent.:lol:
If you use a handgun that propels the bullet at the velocities some of these guns produce, you CAN use hollow-point loads (because of the velocity, they will penetrate to vital organs even on this large game).
CAUTION: If you are carrying these guns to defend against something like a bear, you need to purchase bullets made for these guns. Many times companies will sell HP ammo for these guns that travel 1800 - 2000 fps, but the jackets will seperate coming out of the barrel because the bullets were not made to handle these velocities.
I OC a 454 casull sometimes, and take it with me when I am deep in the woods in a shoulder holster. My load is a 300 gr JHP over 30.0 gr of WIN 296, and I have personally chronographed this load out of my 8 5/8" bbl at 1,750 fps. This will deliver 2,000 foot lbs of energy to whatever you shoot. This is getting close to many popular rifle cartridges (270, 30-06, 308) and actually better than some loads.
A 500 S&W can produce even more muzzle energy than that.:shock:
Either way, I have read many stories online of large african game getting taken with 454 casull from a revolver, and I trust previous results over anything a bullet manufacturer pushes down my throat.
Anything that produces under 1500 ft-lbs of muzzle energy is like throwing a stick at large and dangerous game, and will probably do good to sting a little if you used them to prevent an attack.