I have a Taurus 605 in .38/.357 and keep it loaded with .38 wadcutters. I do that because of a tendency to flinch whenever I come to the second shot of .357. And I think Aooyb is right....if that second shot goes wild and misses the target, it doesn't matter a whit what caliber it happens to be....unless of course, it could hit some innocent bystander after missing the target.
I don't read much about flinching on the various gun forums. And it may be, that I'm the only guy in the country who has trouble with it. I've practiced hard for years, and with due diligence I can shoot without flinching, but after that first hard-kicking .357 magnum recoil, I'm just not sure I can tamp down a natural response to flinch, in a high pressure self-defense situation.
And, "When I'm shooting .357 ammo it kicks but it is controllable. It's not all over the place but it is a noticablekick that makes me have to clamp down on it harder to keep it steady which creates tension on my wrist and probably caused my injury"...the harder I have to hold to a gun, the less accurate I am, since muscle tension makes me pull off.
In my opinion, when it's all said and done, I need to shoot the gun that is least apt to make me miss my target, either through pull off with tension, or flinching.