Once in the hotel room it is a place you are renting or leasing and it is a place you are residing and therefore you can have it loaded and ready while in the room. However, transporting to the hotel room is the question.
There is a lot of discussion about this over on the MDShooters.com forum over the years (use the search feature and use keywords like domicile, bona fide residence, hotel, lease, etc.). There are gray areas still, but there are also ways to possibly avoid some of the gray areas in regards to the transport to and from the hotel room.
But if the handguns are "antique" or "antique replicas" under state law, then transport in a vehicle unloaded is not a problem and is not addressed under state law and is one way to avoid the possible conflicts with transporting to a hotel room.
I am not a lawyer and I did not even sleep in a Holiday Inn Express last night, so double check on anything and everything I state.