I could go on and on with this, but you understand, I'm sure. Two things I would suggest you and her do. Go to a gun show and/or a large gun shop and let her handle a variety of guns. Let her feel the heft and see which ones feel more natural to her in terms of being natural pointers (the gun comes up with virtually no corrections on her part to get a sight picture or good hold). Next, if you can have her fire the guns she has narrowed down in her selection to see how they feel to her.
A very nice, but pricey, gun for women is the Kahr K9. This is an all steel gun with an nice heft and feel, and has a great grip shape and feel for smaller hands. And it's a solid performer. The Glock 26 and 27 are also a good choices, but if she is going to carry in her purse, I would advice against a Glock.
Once again, there is a large selection of some really fine guns for your lady to shop. Good luck and let us know which one she winds up with.