My wife has very small hands, so she's somewhat limited in what she can use effectively, however she loves her Keltec P32. She has also tried and liked the new baby Glock, but she can't work the slide release without extending it.
My advice is to run, don't walk, away from the S&W 642. The fool thing kicks like a mule. Only gun I've ever fired that left my hand numb. My wife developed a flinch from it that has taken years to get rid of.