Heres a great read on the subject on the BEST self defence rounds.When I'm carrying my .357,I have 158 gr HP/XTP 1610fps. rounds in it.In my opinion,the .357 is the best handgun round bar none,the problem with most people is you either get a revolver,with the most,8 rounds in it,or a semi-auto with 9+1 rounds,which will be larger than most will want to carry.
When I carry my .40 S&W,I have the Cor-bon 135 gr. JHP 1325 fps.
ANALYSIS OF VELOCITY:
The faster a bullet is traveling, the more energy is created. Energy developed at the muzzle must be transferred or "dumped" into the target to be effective. Energy transfer is aided by bullet expansion. The higher the velocity, the more rapidly the expansion, the more effectively the energy is expended into the target. This explosive expansion dumps the available energy quickly, creating tremendous shocking power, and causes immediate STOPPING POWER! Stopping Power means SAFETY.