I've often thought about trying to do some kind of testing when I'm out burning thru a couple of hundred rounds but have just never taken the time to do it.
For my carry guns (9mm and 40 S&W) I went with the recommendations in this article. http://www.chuckhawks.com/ammo_by_anonymous.htm Never had to shoot anyone so I don't know if I made the right choice, and I hope I never have to find out. But based upon my research I'm confident that the Cor-Bon 9mm 115 grain +P Jacketed Hollowpoint and .40 Winchester Silvertip 155 grain Jacketed Hollowpoint will do the job if called upon. I use .40 Hornady 165gr FTX in my alternate pistol. It's about twice the weight of my primary carry and is fine to shoot with the heavier slug.