+1 on the above post.
My girlfriend carries a PK 380 (the .380 version of the P22), and I've fired it several times. I believe they are the same other than caliber. The ONLY thing it has going for it is that it is very ergonomic (It just feels[/] right in the hand) and it shoots nicely.
Other than that:
1) It's a complete P.I.T.A. to reassemble. (There's no retention "tube" under the tip of the muzzle, so it just sits in there.) The double wound spring is tiny, and very hard to compress. Added to the lack of any type of spring retention and "SPROING!" I've launched it across the room several times.
2) The mag release is just...plain...funky. A lever? Half the trigger guard is a lever? I guess the simple, easy to use button makes entirely too much sense. That's what I'd like to do if I ever need to reload it in self defense: try to find the lever that swings down from half the trigger guard.
3) Has anyone found a good holster for it? The closest thing I found is a generic "medium frame automatic" holster from Galco. Hope you don't like custom fit holsters designed for a specific model. If you do, your only hope is to go for hyper expensive, hand made jobs like Milt Sparks. I'm not the most patient of people when it comes to buying stuff. I like to walk into the store, find my item, buy it, and leave. Maybe someone here could find a place that sells a specific holster that says "Walther P22" or "Walther PK 380" on the package, but I've been unable to find a specific holster for one. (I have found a kydex model, but it is a package deal with a laser included, and the laser must be installed for it to fit in the holster. Otherwise, it just rattles around, as the holster retains the firearm by clamping the laser.) Until then, the GF is going to have to live with the generic Galco "medium automatic".
I tried suggesting alternative firearms, but she's dead set on the PK 380. Which is fine. Everyone should carry what they feel the most comfortable with, and she likes the way it feels and shoots. Just because I wouldn't personally carry one (I might own one just for plinking) is no reason NOT to own one. As I say, they are very egonomic and fun to shoot. But, IMHO, there are other quality, better built .22's out there that are not only cheaper, but more accurate, and just as much fun.