Before I would venture an opinion, I'd want to know what the courts have decided...
U.S. Courts are notorious for making bad decisions that are later overturned on appeal.
My opinion is that she should stand on the Fifth Amendment. When it's eventually overturned, she'll have the ruling on which she can sue the lower levels for her time and suffering. Should be more than enough for her to retire.
...in matters involving locked automobiles, locked houses and businesses, locked boxes and locked safes. I don't see a material difference between something being encrypted (software locked) file and something being physically secured (hardware locked).
I don't see a material difference there, either. It's akin to merely keeping it locked away in one's brain. If that's where the password is, the judge can order her to reveal it all day long, but if the lady believes doing so will incriminate her, she has the right to plead the 5th: "No person ... shall be compelled in any criminal case to be a witness against himself..."
It does not matter whether it's one's spoken word or if that spoken word which leads to the revelation of written ones. No one can be compelled (ordered by a judge) to say
anything (including a password) that serves as evidence against one's self.
I'm sorry, but Judge Blackburn's order is in error. Apparently, he is either unaware of the nature of computers or the nature of the Fifth Amendment.