Let's talk about what we all know; a well placed shot is a deadly shot. It doesn't matter how big ya gun is if you can't aim the gun.
As one can be witness to in the video -- even a well placed shot can do nothing. I was amazed that a man was hit with a .40S&W that would have severely damaged the heart and it didn't even reach the heart. The round only penetrated about an inch.
People can argue the caliber war all they want, but if a round doesn't have sufficient velocity it will NOT hit vitals. Just because a bullet is heavy does NOT mean it will penetrate. If you are using FMJ then they will penetrate as long as they do not come into contact with heavy bone. If you are using JHP then they will expand and slow down, and this is why velocity is important. It is also extremely important that you carry a round that will not OVER expand, and cause severe drag. You can have a fast load, but if it expands to twice its size or better you will not get sufficient penetration.
There is a guy on Youtube that conducts excellent ballistic tests: his Youtube name is tnoutdoors9 and here is his channel
http://www.youtube.com/user/tnoutdoors9 . Look at SOME of his videos with heavy .45 acp and light 9mm; they just are not sufficient to penetrate properly. Then look at his .357 Sig. videos.
I just recently changed my carry load due (.357 Sig.) to one of his ballistic tests. I used to carry 125 gr. GoldDot, but now I carry 125 gr. Underwood. This Underwood load still uses the excellent GoldDot bullet, but the velocity from my Glock 32 is over 1,500 fps and nearly 650 fpe! This load penetrates and expands very well. You can watch the video here:
http://www.youtube.com/watch?v=ughIFOrIP_w .
He does another video with this CLEAR ballistic gel which is awesome! You can see it here:
http://www.youtube.com/watch?v=iujNWfhUx4A .
I would reccommend everyone check this guy out; I would guaruntee he has probably done a test on the ammo you carry. Not only does he do the tests, but he does them right!