To me, fast access safes in the simplest config are worth considering. IMO, the best would be one that presents your firearm in a properly oriented grip up presentation, like the fas1 safe, or the SV500 gun vault, but no biometrics. Those are still not reliable.
If you do not have kids, it might be reasonable to leave it open at night near the bed, then close it when you get out of bed. That way it's right there and no need to fumble or push buttons. The downside is you have to remember to close it when you exit the bedroom, but if you have layered defense, in truth the only time you would need to close it is if you're going out or going on vacation. After all these devices only make your equipment safe for when you have visitors or housekeeping or a tradesperson working on a utility. All other times, it's available for you to just walk in and grab (again, no kids or unauthorized people in the house).
FWIW